News targets and gene therapy approaches to treat centronuclear myopathies. 2 proteins identified as relevant targets for the different forms of centronuclear myopathies (XL-CNM and AD-CNM). We propose a patents portfolio covering these targets for CNM treatment, based on solid and published proof of concept.

New antibody fragments for the treatment of thrombosis (stroke, thrombotic purpura, coronary syndrome...). Our approach is directed against a platelet receptor that is not currently targeted by commercially available products, and prevents thrombus formation with a reduced bleeding risk.

Human monoclonal antibodies with great neutralizing properties against BK virus. BKV infection causes BKV-associated nephropathy (BKVAN) in kidney transplant recipients, which leads to graft loss or urothelial carcinoma, but can also lead to hemorrhagic cystitis in bone marrow transplant recipients. Our lead antibodies have the ability to be best in class and neutralize BKV with improved efficacy

New target and approach for the treatment of melanoma. Our technology aims at decreasing the expression of a novel long non-coding RNA that has been shown to be essential for the survival and proliferation of melanoma cancer cells using antisense oligonucleotides.

Light-Up Nucleic Acid technology based on a light-up RNA aptamer able to specifically recognize a fluorogen and light up a fluorescence signal.
Module with very good properties in term of brightness, photostability and signal to noise ratio. Could overcome current limitations of RNA imaging and could be applied in diagnostic to detect RNA targets with high specificity and sensibility.

Near-Infrared Coating of Equipment: Fluorescent coating technology of surgical devices with application to Fluorescence Image Guided Surgery. Improves endoscopic procedures thanks to better visualization modalities. FDA approved polymer and original fluorescent dyes with better properties than standards; can be applied to various substrates. A start-up company will be created to develop this tech.

Development of new photopolymerisable formulations for both epoxy and acrylic resins under near-infrared light. These formulations allow a polymerisation within seconds, the near-infrared light allows better penetration than UV and is safer for operators. The technology is an adapted solution for thick or filled samples where UV light fails. This technology targets various markets, such as electronics, automotive or coatings.

Development of a micro-fabricated plate system that allows for the production of organoids that are reproducible in shape and size

First-in-class non peptidergic agonist of oxytocin receptor, with improved activity over endogenous oxytocin, for treatment of social interaction impairments in autism spectrum disorders (ASD)
In vivo preclinical PoC data package: Restore social interaction in ASD mouse model, good safety profile, oral administration

Physisolve is a platform based on AI and a specifically developed algorithm allowing a problem solving. The software guides the formulation of the proble m to be solved and is connected to extensive databases with existing solutions, inspired by nature, physics or engineering.